Yuan B, Scholz J, Wald J, Thuenauer R, Hennell James R, Ellenberg I, Windhorst S, Faix J, and Marlovits TC* (2023)
Structural basis for subversion of host cell actin cytoskeleton during Salmonella infection.
Science Advances DOI 10.1126/sciadv.adj5777
Alexander Simonis A, Kreer C, Albus A, Rox K, Yuan B, Holzmann D, Wilms J, Zuber S, Meyer M, Schmitt K, Gruell H, Theobald SJ, Hellmann A, Munder A, Hallek M, Fätkenheuer G, Koch M, Seifert H, Rietschel E, Marlovits TC, van Koningsbruggen-Rietschel S, Florian Klein F, Jan Rybniker J (2023)
Discovery of highly neutralizing human antibodies targeting multidrug-resistant Pseudomonas aeruginosa.
Cell DOI: 10.1016/j.cell.2023.10.002
Bunduc CM, Ding Y, Kuijl C, Marlovits TC, Bitter W, Houben ENG* (2023)
Reconstitution of a mininal ESC-5 type VII secretion system suggests a role for PPE proteins in the outer membrane transport of proteins.
mSphere 8:e0040223, DOI: 10.1128/msphere.00402-23
Genthe E, Miletic S, Tekkali I, Hennell James R, Marlovits TC*, Heuser P* (2023)
PickYOLO: Fast deep learning particle detector for annotation of cryo electron tomograms
J Struct Biol 215:107990, DOI: 10.1016/j.jsb.2023.107990
Reggiano G, Lugmayr W, Farrell D, Marlovits TC, DiMaio F (2023)
Residue-level error detection in cryoelectron microscopy models.
Structure 31:860-869 DOI 10.1016/J.str.2023.05.002
Wald J, Fahrenkamp D, Goessweiner-Mohr N, Lugmayr W, Ciccarelli L, Vesper O, Marlovits TC* (2022)
Mechanism of AAA+ ATPase-mediated RuvAB-Holliday junction branch migration
Nature 609:630-639.DOI: https://doi.org/10.1038/s41586-022-05121-1
Lugmayr W, Kotov V, Goessweiner-Mohr N, Wald J, DiMaio F, Marlovits TC* (2022). StarMap: a user-friendly workflow for Rosetta-driven molecular structure refinement.
Nature Protocols DOI: 10.1038/s41596-022-00757-9
Seyfert CE, Porten C, Yuan B, Deckarm S, Panter F, Bader C, Coetzee J, Deschner F, Tehrani K, Higgins PG, Seifert H, Marlovits TC*, Herrmann J*, Müller R*. (2022)
Darobactins Exhibiting Superior Antibiotic Activity by Cryo-EM Structure Guided Biosynthetic Engineering.
Angew Chem Int Ed Engl. DOI: 10.1002/anie.202214094
Bergeron JR*, Marlovits TC* (2022)
Cryo-EM of the injectisome and type III secretion systems.
Curr Opin Struct. Biol 75:102403, doi: 10.1016/j.sbi.2022.102403
Killer M, Wald, J., Pieprzyk J, Marlovits TC, Löw C* (2021)
Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Science Advances 7, eabk3259 doi: 10.1126/sciadv.abk3259
Bunduc C, Fahrenkamp D, Wald J, Rummels R, Bitter W, Houben ENG, Marlovits TC* (2021)
Structure and dynamics of the ESX-5 type VII secretion system of Mycobacterium tuberculosis.
Nature 593, 445–448. doi: 10.1038/s41586-021-03517-z
Miletic S, Fahrenkamp D, Goessweiner-Mohr N, Wald J, Pantel M, Vesper O, Kotov V, Marlovits TC* (2021)
Substrate-engaged type III secretion system structures reveal mechanism for unfolded protein translocation.
Nature Communications 12, 1546. https://doi.org/10.1038/s41467-021-21143-1
Yuan B, Portaliou AG, Parakra R, Smit JH, Wald J, Li Y, Srinivasu B, Loos MS, Singh Dhupar H, Fahrenkamp D, Kalodimos CG, Duong van Hoa F, Cordes T, Karamanou S, Marlovits TC*, Economou A (2021)
Structural dynamics of the functional nonameric Type III translocase export gate.
J. Mol. Biol. 167188, https://doi.org/10.1016/j.jmb.2021.167188.
Banger A, Sindram J, Otten M, Kania J, Wilms D, Strzelczyk A, Miletic S, Marlovits TC, Karg M, Hartmann L (2021)
Synthesis and self-assembly of amphiphilic precision glycomacromolecules.
Polym. Chem., 2021,12, 4795-4802 https://doi.org/10.1039/D1PY00422K
Kotov V., Mlynek G, Vesper O, Pletzer M, Wald J, Teixeira-Duarte CM, Celia H, Garcia-Alai M, Nussbaumer S, Buchanan SK, Morais-Cabral JH, Loew C, Djinovic-Carugo K, Marlovits TC* (2020)
In depth-interrogation of or protein unfolding data with MoltenProt.
Protein Sci. 10.1002/pro.3986
Pinotsis N, Zielinska K, Babuta M, Arolas JL, Kostan J, Khan MB, Schreiner C, Salmazo A, Ciccarelli L, Puchinger M, Gkougkoulia EA, Ribeiro EA Jr, Marlovits TC, Bhattacharya A, Djinovic-Carugo K*. (2020)
Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin.
Proc Natl Acad Sci U S A. 117(36):22101-22112. doi: 10.1073/pnas.1917269117
Chabloz A, Schaefer JV, Kozieradzki I, Cronin SJF, Strebinger D, Macaluso F, Wald J, Rabbitts TH, Plückthun A, Marlovits TC*, Penninger JM*. (2020)
Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol.
Commun Biol. 3(1):342. doi: 10.1038/s42003-020-1072-4.
Wald J, Pasin M, Richter M, Walther C, Mathai N, Kirchmair J, Makarov VA, Goessweiner-Mohr N, Marlovits TC, Zanella I, Real-Hohn A, Verdaguer N, Blaas D*, Schmidtke M*. (2019)
Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site.
Proc Natl Acad Sci U S A. 116(38):19109-19115. doi: 10.1073/pnas.1904732116
Kotov V, Bartels K, Veith K, Josts I, Subhramanyam UKT, Günther C, Labahn J, Marlovits TC, Moraes I, Tidow H, Löw C, Garcia-Alai MM*. (2019)
High-throughput stability screening for detergent-solubilized membrane proteins.
Sci Rep. 9(1):10379. doi: 10.1038/s41598-019-46686-8.
Guo EZ, Desrosiers DC, Zalesak J, Tolchard J, Berbon M, Habenstein B, Marlovits T, Loquet A, Galán JE*. (2019)
A polymorphic helix of a Salmonella needle protein relays signals defining distinct steps in type III secretion.
PLoS Biol. 17(7):e3000351. doi: 10.1371/journal.pbio.3000351. eCollection (abstract)
Beckham KSH, Ciccarelli L., Bunduc CM, Mertens HDT, Ummels R, Lugmayr L, Mayr J, Rettel M, Savitski MM, Svergun DI, Bitter W, Wilmanns M, Marlovits TC*, Parret AHA, Houben ENG.(2017) Structure of a mycobacterial type VII secretion system membrane complex. Nature Microbiology 2:17047 (doi 10.1038/nmicrobiol.2017.47)
Song M , Sukovich DJ, Ciccarelli L, Mayr J, Fernandez-Rodriguez J, Mirsky EA, Tucker AC, Gordon DB, Marlovits TC, Voigt CA (2017)
Control of type III protein secretion using a minimal genetic system
Nature communications 8:14737 (doi 10.1038/ncomms14737)
Dietsche T, Tesfazgi Mebrhatu M, Brunner MJ, Abrusci P, Yan J, Franz-Wachtel M, Schärfe C, Zilkenat S, Grin I, Galán JE, Kohlbacher O, Lea S, Macek B, Marlovits TC, Robinson CV, Wagner S. (2016)
Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus.
PLoS Pathog. 12:e1006071. (doi: 10.1371)
Smaldone G, Pirone L, Pedone E, Marlovits T, Vitagliano L, Ciccarelli L. (2016)
The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.
FEBS Lett. 590:1663-71
DiMaio F, Song Y, Li X, Brunner MJ, Xu C, Conticello V, Egelman E, Marlovits TC, Cheng Y, Baker D (2015)
Atomic accuracy models from 4.5 Å cryo-electron microscopy data with density-guided iterative local rebuilding and refinement.
Nature Methods 12:361-365 (doi:10.1038/nmeth.3286)
Galan JE *, Lara-Tejero M, Marlovits TC, Wagner S (2014)
Bacterial Type III Secretion Systems: Specialized Nanomachines for Protein Delivery into Target Cells
Ann Rev Microbiol 2014;68:415-38. doi: 10.1146/annurev-micro-092412-155725
Hornung P, Troc P, Malvezzi F, Maier M, Demianova Z, Zimniak T, Litos G, Lampert F, Schleiffer A, Brunner M, Mechtler K, Herzog F, Marlovits TC, Westermann S
A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A
Journal of Cell Biology (DOI 10.1038/nsmb.2722)
comment: A new piece in the kinetochore jigsaw puzzle Corbett KD and Desai A
206:457-459. doi:10.1083/jcb.201407048
Radics J, Königsmaier J, Marlovits TC* (2014)
Structure of a pathogenic type-3 secretion system in action.
Nature Structural and Molecular Biology (DOI 10.1038/nsmb.2722)
Simunovic M, Mim C, Marlovits TC, Resch G, Unger VM, Voth GA* (2013)
Protein-mediated transformation of lipid vesicles into tubular networks.
Biophys J 105(3):711-9 (abstract)
* Highlighted as Cover in Biophys J
Brunner MJ, Fronzes, R.*, Marlovits TC* (2013)(in press)
Envelope Spanning Secretion Systems in Gram-negative bacteria.
In: Bacterial Membranes: Structural and Molecular Biology (Eds Remaut H, Fronzes R)
Horizon Press ISBN: 978-1-908230-27-0
Fernandez-Rodriguez J., Marlovits TC* (2012)
Induced heterodimerization and purification of two target proteins by a synthetic coiled-coil tag
Protein Science (in press) (abstract)
*Highlighted, Protein Science, 21 (4), 2012
Kosarewicz A., Königsmaier L., Marlovits TC* (2012)
The blueprint of the Type-3 Injectisome. (abstract)
Phil Trans Royal Society B 367(1592):1140-54
Schraidt O., Marlovits TC* (2011)
Three-dimensional model of Salmonella’s Needle Complex at Subnanometer Resolution.
Science 331:1192-95 (abstract)
* Perspectives, Science, 331:1147-1148
* This week in Science: Science 331:1109)
Khan AG, Pickl-Herk A, Gajdzik L, Marlovits TC, Fuchs R, Blaas D. (2011)
Entry of a heparan sulphate-binding HRV8 variant strictly depends on dynamin but not on clathrin, caveolin, and flotillin.
Virology (abstract)
Galkin, VE., Schmied, WH., Schraidt, O., Marlovits, TC*., Egelman, EH*. (2010).
The structure of the Salmonella typhimurium type III secretion system needle shows divergence from the flagellar system.
J Mol Biol. 396(5):1392-7 (abstract)
Khan, AG., Pickl-Herk, A., Gajdzik, L., Marlovits, TC., Fuchs, R., Blaas, D. (2010).
Human rhinovirus 14 enters rhabdomyosarcoma cells expressing icam-1 by a clathrin-, caveolin-, and flotillin-independent pathway.
J Virol. 84(8):3984-92 (abstract)
Marlovits, TC*, Stebbins, CE*. (2010).
Type III secretion systems shape up as they ship out.
Curr Opin Microbiol. 13(1):47-52 (abstract)
Schraidt, O., Lefebre, MD., Brunner, MJ., Schmied, WH., Schmidt, A., Radics, J., Mechtler, K., Galán, JE., Marlovits, TC* (2010).
Topology and organization of the Salmonella typhimurium type III secretion needle complex components.
PLoS Pathog. 6(4):e1000824 (abstract)
Wagner, S., Königsmaier, L., Lara-Tejero, M., Lefebre, M., Marlovits, TC*, Galán, JE* (2010).
Organization and coordinated assembly of the type III secretion export apparatus.
Proc Natl Acad Sci U S A. 107(41):17745-50 (abstract)
Marlovits, TC., Kubori, T., Lara-Tejero, M., Thomas, D., Unger, VM., Galán, JE* (2006).
Assembly of the inner rod determines needle length in the type III secretion injectisome.
Nature. 441(7093):637-40 (abstract)
Marlovits, TC., Kubori, T., Sukhan, A., Thomas, DR., Galán, JE*, Unger, VM* (2004). Structural insights into the assembly of the type III secretion needle complex.
Science. 306(5698):1040-2 (abstract)
* This week in Science: Science 306:937
Marlovits, TC., Haase, W., Herrmann, C., Aller, SG., Unger, VM* (2002).
The membrane protein FeoB contains an intramolecular G protein essential for Fe(II) uptake in bacteria.
Proc Natl Acad Sci U S A. 99(25):16243-8 (abstract)
*Editor’s choice in Science Signalling Sci. Is FeoB the Missing Link in GPCR Evolution?
STKE 2002 (163), tw470. [DOI: 10.1126/stke.2002.163.tw470]
Hewat, EA., Neumann, E., Conway, JF., Moser, R., Ronacher, B., Marlovits, TC., Blaas, D* (2000).
The cellular receptor to human rhinovirus 2 binds around the 5-fold axis and not in the canyon: a structural view.
EMBO J. 19(23):6317-25 (abstract)
Ronacher, B., Marlovits, TC., Moser, R., Blaas, D* (2000).
Expression and folding of human very-low-density lipoprotein receptor fragments: neutralization capacity toward human rhinovirus HRV2.
Virology. 278(2):541-50 (abstract)
Verdaguer, N., Marlovits, TC., Bravo, J., Stuart, DI., Blaas, D., Fita, I* (1999).
Crystallization and preliminary X-ray analysis of human rhinovirus serotype 2 (HRV2).
Acta Crystallogr D Biol Crystallogr. 55(Pt 8):1459-61 (abstract)
Hewat, EA., Marlovits, TC., Blaas, D* (1998).
Structure of a neutralizing antibody bound monovalently to human rhinovirus 2.
J Virol. 72(5):4396-402 (abstract)
Marlovits, TC., Abrahamsberg, C., Blaas, D* (1998).
Very-low-density lipoprotein receptor fragment shed from HeLa cells inhibits human rhinovirus infection.
J Virol. 72(12):10246-50 (abstract)
Marlovits, TC., Abrahamsberg, C., Blaas, D* (1998).
Soluble LDL minireceptors. Minimal structure requirements for recognition of minor group human rhinovirus.
J Biol Chem. 273(50):33835-40 (abstract)
Marlovits, TC., Zechmeister, T., Gruenberger, M., Ronacher, B., Schwihla, H., Blaas, D* (1998).
Recombinant soluble low density lipoprotein receptor fragment inhibits minor group rhinovirus infection in vitro.
FASEB J. 12(9):695-703 (abstract)
Marlovits, TC., Zechmeister, T., Schwihla, H., Ronacher, B., Blaas, D* (1998).
Recombinant soluble low-density lipoprotein receptor fragment inhibits common cold infection.
J Mol Recognit. 11(1-6):49-51 (abstract)
Ayasse, M*, Marlovits T., Tengö, J., Taghizadeh, T., Francke, W. (1995).
Are there pheromonal dominance signals in the bumblebee Bombus hypnorum L. (Hymenoptera, Apidae)?
Apidologie. 26:163-180
Publications (* corresponding author)
